Capsule suspension(cS)
Description
Capsule suspension (CS) is formulation containing active ingredient encapsulated by synthetic or natural polymer materials, and the microcapsules suspend in an aqueous phase.
Benefits
- Deliver controlled release and have a persistent effect
- Lower toxicity,reduce odor and contact toxicity, significantly enhance work safety
- Reduced phytotoxicity
- Increase product stability and compatibility in tank mixes
- 30-100% reduction in organic solvent usage, mitigate environmental risks
Limitaions
- Due to its slow-release nature, its rapid-acting properties are significantly reduced and it is not suitable for use in rapid-acting scenarios
Chemical processes
In-situ polymerization
In-situ polymerization is the technique that one or two water-soluble monomers are added to the aqueous phase, polymerization take place and yield polymer microparticles, polymers deposited on the surface of the core material to form microcapsules.
Interfacial polymerization
Interfacial polymerization is another commonly used encapsulation technique. In this process, reactive monomers or prepolymers are dissolved in two immiscible phases. Upon droplet formation by dispersion, polymerization takes place on the interface and results in microcapsule formation. Interfacial polymerization method requires one monomer is water-soluble and the other is oil-soluble.

Characterization of capsule suspension
| Item | Test method |
|
Microstructure |
optical microscopy、SEM、TEM |
|
Particle size distribution |
MT 187 laser particle analyzer |
|
Active ingredient |
high performance liquid chromatograph |
|
Encapsulated content |
filtration method |
|
Suspensibility |
MT 184 |
|
Release rate |
methods under development |
|
Stability at elevated temperature |
MT 46.3 14-day stability at 54℃ |
|
Freeze/thaw stability |
the freeze/thaw stability test shall cycle the formulation between room temperature (e.g. 20 ± 2°C) and -10 ± 2°C on 18-hour-freeze/6-hour-melt cycles for a total of 4 cycles |
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