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Capsule suspension(cS) 

 

 

Description

 

Capsule suspension (CS) is formulation containing active ingredient encapsulated by synthetic or natural polymer materials, and the microcapsules suspend in an aqueous phase.

 

Benefits

 

  • Deliver controlled release and have a persistent effect
  • Lower toxicity,reduce odor and contact toxicity, significantly enhance work safety
  • Reduced phytotoxicity
  • Increase product stability and compatibility in tank mixes
  • 30-100% reduction in organic solvent usage, mitigate environmental risks

 

Limitaions

 

  • Due to its slow-release nature, its rapid-acting properties are significantly reduced and it is not suitable for use in rapid-acting scenarios

 

Chemical processes

 

In-situ polymerization

In-situ polymerization is the technique that one or two water-soluble monomers are added to the aqueous phase, polymerization take place and yield polymer microparticles, polymers deposited on the surface of the core material to form microcapsules.

 

Interfacial polymerization

Interfacial polymerization is another commonly used encapsulation technique. In this process, reactive monomers or prepolymers are dissolved in two immiscible phases. Upon droplet formation by dispersion, polymerization takes place on the interface and results in microcapsule formation. Interfacial polymerization method requires one monomer is water-soluble and the other is oil-soluble.

 

microencapsulation by interface polymerization procedure

 

Characterization of capsule suspension

 

Item Test method

Microstructure

optical microscopy、SEM、TEM

Particle size distribution

MT 187

laser particle analyzer

Active ingredient

high performance liquid chromatograph

Encapsulated content

filtration method

Suspensibility

MT 184

Release rate

methods under development

Stability at elevated temperature

MT 46.3

14-day stability at 54℃

Freeze/thaw stability

the freeze/thaw stability test shall cycle the formulation between room temperature (e.g. 20 ± 2°C) and -10 ± 2°C on 18-hour-freeze/6-hour-melt cycles for a total of 4 cycles

 

 

 

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